Published Paper Details:

The most prevalent gynecological condition that affects women is leiomyoma, also known as uterine fibroids. Up until now, surgical procedures such as myomectomy or total abdominal hysterectomy have been used to treat symptomatic fibroids. Patients are increasingly searching for minimally intrusive, uterus-protecting therapy or preventative for asymptomatic or symptomatic uterine fibroids in order to lessen the burden of surgery. Fibroids and related uterine issues have been treated with medicinal plants and herbs and their active phytoconstituents. Thus, the processes by which phytochemicals alter fibroid growth pathways are highlighted in this review. The herbs and phytoconstituents that have been investigated the most include Scutellaria Barbata D. Don, Curcuma longa L. (turmeric), resveratrol, curcumin, and anthocyanins, respectively. These are utilized treatment or prevention to suppress fibroid growth/proliferation pathways. Additionally, cell-cycle arrest, death triggered by ROS levels above the threshold of cell viability, and the inhibition of ECM proteins through growth factor decrease were the primary targets for fibroid inhibition. This review provides important insights for creating novel and creative therapeutic alternatives for the management of symptoms in women with uterine fibroids by highlighting natural anti-fibroid phytoextracts and the pharmacological mechanism by which they control fibroid pathways.