Published Paper Details:

Abstract: Topical drug delivery system is a painless route of drug administration. There are different skin diseases and infections caused by fungus and microorganisms. which are treated with the probiotics or living microorganism which are used as active pharmaceutical agent. The purpose of writing this review article was to compile the recent literature with a special focus on a rational approaches of topical probiotic gel formulation and basic components of topical drug delivery systems. Topical applications of drugs have advantages of delivering the drug directly at the site of action and acting for a prolong period of time. Skin is one of the most widespread and important accessible organs on the human body for topical incorporation. it is the main route of topical drug delivery system. Many widely used topical probiotic products like ointments, creams and lotions have number of disadvantages as they are usually very sticky causing un-comfort to the patient after application. Moreover, they also have less spreading coefficient and need to apply with rubbing and also have the problem of stability , due to all these factors, within the major group of semisolid preparations; the use of gels has increased both in cosmetics and in pharmaceutical preparations because, A probiotic gel is colloid and it is typically 99% by weight formed by liquid material, which is immobilized by surface tension between it and a macromolecular network of fibers built from a small amount of a gelatinous ingredient present in the formation. In this revive we discus about the general Prepration and evaluation of probiotic gel