Published Paper Details:

The skin consists of different cell types that express certain molecules and have different properties, and provides the interaction and intercellular communication that is important for the continuity of the skin. Additionally, a change in one of the molecules can affect the entire organization and function of these important networks, causing cell detachment, blistering, and other conditions in the skin. Phenotypes will emerge. Over the past few decades, the genetic basis of various monogenic skin diseases has been elucidated using classical genetic methods. More importantly, the results of these studies demonstrate the importance of different types of molecules and genetic and molecular interactions that lead to irreversible changes in the skin. With the advent of the Human Genome Project, next-generation sequencing technologies, and several other recent advances, progress has been made in reducing genetic variation rather than the Mendelian gene behind the monster patterns of genetic diseases. Over the past few years, progress has been made in uncovering the genes underlying various skin diseases and various phenotypes. Many molecules are directly involved in the pathogenesis of these diseases, many of which have been discovered through genetics and are discussed in detail in this chapter. These techniques help determine the genetics of monogenic skin diseases. Recently, the genetic basis of non-Mendelian dermatoses has begun to emerge, with many regions involved in their pathogenesis