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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
Determination of Levosalbutamol and Guaiphenesin in Pharmaceutical dosage form by Simultaneous and Q-analysis UV-Spectrophotometric method
Authors
Prof. Prashantsingh Shersingh Utale, S A Quazi
Keywords
Levosalbutamol and Guaiphenesin, UV-Spectrophotometry, Simultaneous equation method, Q-Analysis method, UV method.
Abstract
Two simple, accurate and precise UV methods were developed for the estimation of Levosalbutamol and Guaiphenesin in Bulk drug form. Both the drugs are used in treatment of chronic bronchitis and mild to moderate pneumonia and muscle spasm. Method A is Simultaneous equation method; wavelengths selected for Quantitation are 271.0 nm and 245.5 nm for Levosalbutamol and Guaiphenesin respectively which are the ?max of both the drugs. Method B is Q -Analysis method, wavelengths selected were 245.5nm (?max of AMB) and 244.0 nm (Isobastic point) for the analysis. In both the methods linearity for detector response was observed in the concentration range of 10-60mcg/ml for 2-12 respectively. The results of bulk drug analysis for method A is found to be 99.66% + 0.49 S.D for 99.99% + 0.08 S.D for and results obtained for Method B is 99.75% + 0.41 S.D for 99.77 % + 0.44 S.D. The proposed methods were successfully applied for the simultaneous determination of both the drugs in commercial tablet preparation. The results of the analysis have been validated as per ICH rules.
IJCRT's Publication Details
Unique Identification Number - IJCRT24A3131
Paper ID - 253754
Page Number(s) - j572-j576
Pubished in - Volume 12 | Issue 3 | March 2024
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Prof. Prashantsingh Shersingh Utale, S A Quazi, "Determination of Levosalbutamol and Guaiphenesin in Pharmaceutical dosage form by Simultaneous and Q-analysis UV-Spectrophotometric method", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.12, Issue 3, pp.j572-j576, March 2024, Available at :http://www.ijcrt.org/papers/IJCRT24A3131.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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