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Abstract Background Giving birth to a child is the yearning of every woman and if this wish is not fulfilled, it is associated with lots of psychological problems such as anger, betrayal, guilt, sadness, jealousy, self-esteem, anxiety, depression, and poor quality of life. Society always expects that a couple will have a child just after their marriage, but it is actually very destructive and heart-breaking feeling that they want to have children but they cannot. Infertility can be a stressful experience. Some research Trusted Source suggests that stress may impact the likelihood of conceiving, although there is not enough evidence to confirm a causative link. Some medical issues affecting fertility, such as polycystic ovary syndrome (PCOS), may also increase the risk of depression. Research suggests that depression and anxiety may be three times higher in infertility women receiving treatment. OBJECTIVES OF STUDY ? To assess the Psychological Distress among infertile women ? To find out association between the psychological distress among infertile women with selected socio demographic variables Methodology The study used a non-experimental methodology, a descriptive cross sectional research design and a non-randomized purposive sampling technique. 30 infertile women assessed by using DASS-21, along with inclusion and exclusion criteria, in order to gather data from respondents. The tool had 21 items that assessed Psychological Distress. Both descriptive and inferential statistics were used to describe the outcomes. Results Based on the study's findings, mild psychological distress among infertile women undergoing treatment at selected infertile clinics depression 28 (6.66%), anxiety 12 (40.00%). Psychological distress among infertile women and association with socio-demographic variables, educational status and monthly income shows significant and other socio-demographic variables found no significant at 0.05 (5%) level. Interpretation and Conclusion Infertility can cause psychologically distress, emotionally stress and financial difficulties for both partners. Typical reactions to infertility include shock, sadness, depression, anger and frustration, loss of self-esteem and self-confidence and a general loss of sense of control. The diagnosis of infertility can be an overwhelming burden for women. This diagnosis may lead to major psychiatric disorders such as depression, anxiety and low self-esteem. Therefore, women should be offered counseling and support as they undergo infertility treatment. It has been well documented that psychological interventions for women with infertility have the capacity to reduce symptoms of anxiety and depression and significantly increase pregnancy rates.