Published Paper Details:

Abstract:- This Research Investigate the uses of polyherb transdermal patches for wound healing, Wound healing is a complex biological process that consists of hemostasis, inflammation, proliferation, and remodeling. The in-vivo wound healing efficacy of the polyherb patch was observed to perform better in terms of wound closure after 14 days as compared to conventional cotton gauze. Methodology includes the combination of tulsi, neem& alove vera extract with Excipients methanol, PEG, HPMC, Chloroform, propylene glycol etc. are steer with the help of magnetic stirrer. And then dry the mixture in hot air oven at 50 degree Celsius. neem showed significant changes in the healing process by enhancing the proliferation phase. The anti-bacterial, anti-inflammatory, anti-fungal, and anti-viral characteristics of neem's active components, such as nimbidin, nimbin, and nimbidol, aid in promoting the healing of wounds. We also find out that Aloe Vera is effective In inhibiting inflammatory reaction by inhibition of IL-6 and IL-8, it reduces the adhesion of WBC and also decrease TNF alpha Levels. Aloe Vera increases amount of collagen in wound and also tends to change composition of collagen. It Also increases the cross linking then hence it promotes wound healing. Various Research Study and Surveys States that there are Topical and Transdermal Medicated Formulation for Dealing with Treatment of Skin Infections but this Study States the Transdermal Drug Delivery System Has wide range of Advantages over Topical Formulation. This TDDS has wide scope in future so it involves various New Approaches like Iontophoresis, Photomechanical waves etc.