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The Unani system of medicine, originating from ancient Egypt & Mesopotamia, developing in Greece and enriched by Persian and Arab traditions, finds a fertile ground in India's diverse natural environment. India's varied climate and geographical features contribute to a rich biodiversity that supports a wide array of medicinal herbs and plants integral to Unani pharmacopeia. Among these medicinal plants, Khurfa (Portulaca oleracea Linn.), known as purslane in English, holds a prominent place in Unani medicine due to its multifaceted medicinal properties. Purslane has been traditionally used for centuries across different cultures for its therapeutic benefits. Its leaves, stems, and seeds are utilized in various formulations to treat a range of ailments. Khurfa (Portulaca oleracea L.) exemplifies the integration of natural remedies into the Unani system of medicine, leveraging India's rich biodiversity to harness the plant's therapeutic potential. Its widespread use across different cultures emphasizes its efficacy and safety in traditional medicinal practices. Purslane continues to be studied for its pharmacological properties, reinforcing its importance in contemporary herbal medicine and as a source of sustainable healthcare solutions. It has been extensively detailed in this article.