Published Paper Details:

The sustained release system includes any drug delivery system that achieves slow and extended release of drug over an extended period of time. The present study was carried out to develop and evaluate the matrix tablets of Metformin HCl 500 mg strength containing cellulose derivatives as release modifying polymer. The matrix tablets of 500 mg strength were prepared by direct compression. The data generated from in-vitro studies showed, the drug release from matrices containing HPMCK100M was based on diffusion and erosion. Therefore, HPMCK100M can be used to modify release rate of Metformin HCl in matrix tablets. The results of in-vitro drug release studies in simulated GI fluids was showed that matrix tablets containing HPMC K100M in (F-5) batch in direct compression are able to control the release of water-soluble Metformin HCl. Therefore it was concluded that HPMCK100M is suitable for the formulating matrix system of Metformin HCl. Metformin HCL was stable in the designed matrices.