Published Paper Details:

Garcinol, a polyisoprenylated benzophenone derived from the Garcinia indica fruit, has garnered significant interest for its multifaceted therapeutic properties. This review synthesizes research done on garcinol's effects on various diseases, including diabetes, cancer, ulcerative conditions, and neurodegenerative disorders. In diabetes, garcinol exhibits antidiabetic potential by modulating glucose metabolism and enhancing insulin sensitivity. Its anticancer properties are profound, characterized by the inhibition of cell proliferation, induction of apoptosis, and suppression of metastasis across various cancer types. Garcinol also demonstrates potent antiulcer activity, providing gastric mucosal protection through antioxidant and anti-inflammatory mechanisms. Additionally, garcinol shows promise in neuroprotection, mitigating oxidative stress, and neuroinflammation, which are pivotal in the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's. Despite these promising findings, clinical studies are necessary to confirm these effects and understand the underlying molecular mechanisms comprehensively. This review underscores garcinol's potential as a therapeutic agent and highlights the need for further research to explore its full medicinal capabilities.