Published Paper Details:

This abstract presents an overview of St. John's Wort (Hypericum perforatum L.), highlighting its pharmacognostic characteristics, bioactive constituents, antidepressant activity, adverse effects, marketed preparations, and uses. Pharmacognostically, St. John's Wort is identifiable by its distinctive yellow flowers and perforated leaves. Its bioactive constituents, including hypericin, hyperforin, and flavonoids, are responsible for its antidepressant activity through the inhibition of neurotransmitter reuptake. While effective in managing mild to moderate depression and anxiety, St. John's Wort exhibits adverse effects such as gastrointestinal disturbances and photosensitivity, along with potential drug interactions. Various commercial preparations, including capsules, tablets, extracts, and teas, are available in the market, differing in concentrations of bioactive constituents. Despite its therapeutic benefits, caution is warranted in its use due to adverse effects and interactions. In conclusion, St. John's Wort represents a promising herbal remedy for mood disorders, necessitating careful consideration of its safety profile and standardization of formulations to ensure optimal therapeutic outcomes.