Published Paper Details:

Controlled drug delivery systems ensure a consistent drug concentration at the absorption site, enabling the maintenance of plasma levels within the therapeutic range. This not only reduces side effects but also lessens the need for frequent administration. Sustained-release (SR) oral products offer a distinct advantage compared to traditional dosage forms. They optimize drug properties, minimizing dosing frequency to a point where a once-daily dose effectively manages therapeutic needs. This approach ensures uniform plasma concentration, maximizing drug utility while minimizing local and systemic side effects. It accelerates the cure or control of conditions in the shortest possible time using the smallest drug quantity, promoting greater patient compliance. The development of controlled drug delivery systems aims to address challenges linked to traditional drug delivery methods. These systems administer the drug at a predefined rate, either locally or systemically, over a specified duration. Controlled release formulations decrease the necessary daily dosing frequency. Over the last two decades, there has been significant progress in controlled drug delivery systems, spanning from macro-scale to nano-scale, incorporating intelligent targeted delivery strategies. Controlled or modified release drug delivery systems enable the gradual administration of drugs over an extended duration. These systems encompass various dosage forms, including those for oral and transdermal use, as well as injectable and implantable options. Although the oral route is generally the preferred method for drug administration, some molecules face challenges like low bioavailability due to solubility or permeability issues.