Published Paper Details:

The study aimed to develop buccal tablets of Ivabradine HCl, focusing on mucoadhesive properties. Various polymers, including Natrosol 250 M, Natrosol 250 HHX, Natrosol 250 G, and Carbopol 934 P, were employed via direct compression. Infrared spectrum analysis confirmed no drug-polymer interactions. Tablets met pharmacopoeial standards for weight, hardness, thickness, friability, and drug content. Their surface pH indicated safe mucosal use. Swelling up to 8 hours in distilled water ensured bioadhesion integrity. In-vitro release extended to 8 hours, with formulation F6 exhibiting 99% drug release, hence chosen for optimization using factorial design. Factorial batches (I1-I9) with Carbopol 934 P and Natrosol as variables showed significant outcomes. Batch I8 achieved desired drug release. Batch O1 was fine-tuned for drug release and mucoadhesive strength, releasing 99% over 8 hours, with good permeability. Zero order was determined to be the best-fitting model (R2 = 0.99832), suggesting non-Fickian diffusion. Stability assessment over a month confirmed formulation stability. Batch O1 outperformed a commercial product, becoming the optimized formulation.