Published Paper Details:

Microspheres are spherical particles with diameters typically ranging from tens to hundreds of micrometers, extensively utilized in various fields including pharmaceuticals, biotechnology, and materials science. Among the methods employed for their formulation, solvent evaporation stands out as a versatile and widely adopted technique. This abstract aims to provide a concise overview of the process involved in formulating microspheres via solvent evaporation. The process begins with the dissolution of a polymer or a blend of polymers in a volatile solvent, forming a homogeneous solution. Optionally, an emulsification or dispersion step may follow to encapsulate hydrophilic substances or control release properties. Subsequently, the polymer solution is subjected to controlled evaporation to remove the solvent gradually. As the solvent evaporates, the polymer precipitates, leading to the formation of solid microspheres. Parameters such as polymer choice, solvent selection, and processing conditions are carefully optimized to achieve desired microsphere characteristics. Solvent evaporation offers several advantages including precise control over particle size and morphology, versatility in encapsulating both hydrophobic and hydrophilic substances, and compatibility with various polymers and active ingredients. However, optimization of process parameters is critical to ensure the desired characteristics and performance of the microspheres.