Published Paper Details:

A potentially effective method of bypassing the barrier between the blood and the brain and delivering medicinal substances straight to the brain is the nose-to-brain medication delivery system. The state-of-the-art in nose-to-brain medication delivery systems is thoroughly reviewed in this paper, with an emphasis on recent developments, difficulties, and potential future directions. The nasal route has several benefits for delivering drugs to the brain, such as a rich blood supply, a wide surface area, and the ability to bypass first-pass metabolism. To improve medication transport through the nasal passages to the brain, a number of approaches have been investigated, such as the use of mucoadhesive formulations, nasal irrigation methods, and nanocarriers. The efficiency & targeting abilities of nose to brain delivery systems are significantly enhanced by nanotechnology. medications may be delivered continuously and with regulated release thanks to nanocarriers including liposomes, nanoparticles, and nano emulsions, which also increase the medications' bioavailability and therapeutic effectiveness. By limiting systemic adverse effects, surface modification approaches enable tailored delivery to certain brain areas. By maintaining longer contact with the nasal mucosa and facilitating absorption into the systemic circulation or direct transfer to the brain, mucoadhesive formulations improve medication retention in the nasal cavity. Mucoadhesive systems based on polymers, such hydrogels and microspheres, have shown potential in enhancing medication absorption and retention. Nasal irrigation methods provide a non-invasive and patient-friendly way to administer medication. These methods include nasal sprays and nebulizers. By administering medications in an aerosolized form, these devices enable quick absorption through the nasal epithelium and direct delivery of the medication to the brain through the olfactory and trigeminal pathways. Even with great advancements, there are still a number of issues with nose-to-brain medication administration that need to be resolved, such as the removal of nasal mucociliary cells, the breakdown of enzymes, and architectural obstructions in the nasal canal. In addition, a thorough assessment of the long-term impacts on the nasal mucosa and the safety profile of nanocarriers is required. Neap-to-brain medication delivery devices are particularly promising for treating Parkinson's disease, Alzheimer's disease, and brain tumors, among other neurological conditions. To fully realize the promise of this novel technique in clinical practice, more study is needed to overcome current obstacles and optimize delivery strategies.