Published Paper Details:

The use of certain drugs during the pregnancy might pose a risk to the developing foetus, raising concerns about the potential adverse effects on the foetal development and maternal health. This abstract will provide an overview of the intolerant drugs during pregnancy, focusing on their pharmacological activities, mechanism of crossing the placental barrier, and associated risks. Drugs that cross the placenta can impact foetal development by affecting the organs and systems, which leads to the congenital abnormalities and many other complications. The main factors that might influence the passage of the drug to the foetus might be the size, molecular weight, ionisation, or its binding strength. Some common examples of the ''Intolerant Drugs'' are: Thalidomide, ACE Inhibitors, Warfarin, Tetracyclines, Retinoids, and Ribavirin. All of these drugs have been evident to show some severe birth defects like limb abnormalities, kidney functioning issues, heart defects, or sometimes it can be fatal. It's important to note that the assessment of drug safety during pregnancy is complex, and varies under different circumstances. Healthcare workers play a crucial role in the evaluation of the risks and benefits of medication use in each case, considering factors such as the specific drug, the trimester of pregnancy, the health status of the pregnant individual, and alternative treatment options. Henceforth, this Abstract emphasises on the importance of medical guidance and reducing the risks associated with drug exposure during the pregnancy.