Published Paper Details:

Excellent and broad bio-spectrum of amide derivatives has generated an attractive platform for synthetic chemists to introduce structural modification in its nucleus by conventional access to new approaches. A new sequences of various amide derivatives have been design and synthesized. The methodology is proficient and simple to perform, giving the desired amides with excellent yield. An innovative series of four derivatives of amide were synthesized by the condensation of different compound like acetanilide, aniline, sulphanilamide and urea with benzoyl chloride in presence of sodium hydroxide as a catalyst. The reactions steps and the purity of the products were crisscross by using Thin Layer Chromatography (TLC). The chemical structure of final compounds were characterized and inveterate by measuring their melting points, elemental analysis, IR and 1H-NMR. The in-vitro antibacterial activity is done by using disc diffusion methods. The compounds were confirmed at different concentration from 0.02-0.10mg/ml in order to plaid the percentage inhibition of compounds. From the result compounds A1 and A2 presented highly significant activity against gram positive bacteria in comparison to standard sulphanilamide. A preliminary study of antimicrobial activity was performed in which antibacterial activity was done in two strains of bacterial activity was done. The results showed that compounds A1 and A2 have significant antibacterial activity compared with standard drugs and the other tested compounds have moderate to good activity.