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Despite signing up to various Acts and Conventions on mental health, the violation of their rights are continuing around the globe. This may be due to the lack of knowledge and faulty attitude of community and also some poor beliefs are contributing to this. Investigator felt that the 3rd year BSc. Nursing students would be the best resource as they will be the future teachers and staff nurses. So by educating these students regarding human rights of mentally ill, the knowledge will be communicated to co workers and students about protection of human rights to mentally ill. It is necessary that everyone should be aware of human rights to mentally ill.. Method: An evaluative approach was adopted for the study with one group pre test post test design. 30 samples were selected using non probability purposive sampling technique and the data was collected using a structured knowledge questionnaire on human rights of mentally ill. The main study was done in Amaltash College of Nursing, Dewas, M.P. Result: Comparison of overall knowledge score in pretest and posttest reveals that BSc. Nursing students are having 39.9% more knowledge in posttest than pretest. This 39.9% of knowledge gain is the net benefit of this study, which indicates the effectiveness of STP. Before the administration of Self Instructional module, 80% of BSc. nursing students had inadequate knowledge, 20% of them had moderate knowledge and none of them had adequate knowledge. After the administration of Structured teaching programme on human rights of mentally ill, none of them had inadequate knowledge, 26.66% of them had moderate knowledge and 73.33% of them had adequate knowledge. Pearson Chi square test was used to test statistical significance; it is statistically significant at 0.01 level. Conclusion: Descriptive and inferential statistics were employed to analyze the data. The data analysis was carried out on the basis of objectives and hypotheses of the study and has been presented on the sample characteristics with their knowledge. The overall pretest scores was 37.4 % and the posttest scores was 76.4%. There was association between posttest knowledge score and selected socio-demographic variables., source of past information, theory classes attended by students are significantly associated with posttest level of knowledge. The independent 't' value was 24.79 % which was greater than the table value at P<0.001 level of significance. This indicated that STP was significantly effective in enhancing the knowledge of BSc nursing students.