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The research objectives of this study encompass the identification of socio-demographic characteristics, the evaluation of knowledge levels, the comprehension of the effects of menstruation, and the examination of menstrual hygiene practices among the participants. Utilizing a cross-sectional descriptive design, data was obtained from 400 secondary school girls from Yakubia Girl's High School. The study was conducted from September 2019 to March 2020. The survey, which was based on questionnaires, encompassed various aspects such as socio-demographic characteristics, knowledge about menstruation, and hygiene practices. The statistical analysis was performed by employing SPSS software. The findings divulged that the majority of participants were below the age of 16, with a significant number of girls experiencing menarche at or before the age of 13. The primary source of knowledge about menstruation for the girls was their mothers, followed by sisters and friends. Nevertheless, there were gaps in understanding the definitions and cycles of menstruation, with numerous girls lacking knowledge regarding menstrual hygiene prior to experiencing menarche. The study underscores the significance of comprehensive education about menstruation and the availability of hygienic facilities for adolescent girls. It advocates for targeted interventions aimed at enhancing menstrual hygiene practices and tackling the cultural taboos associated with menstruation. By augmenting the knowledge of girls and providing adequate support, the study strives to alleviate the adverse effects of menstruation on education and empower adolescent girls in Bogura, Bangladesh. The study investigates the socio-demographic characteristics, awareness levels, and practices related to menstruation among secondary school girls in a particular region. Findings reveal that mothers predominantly impart knowledge about menstruation, with limited influence from other sources. Participants commonly experience physical and mental challenges during menstruation, impacting their schooling. Recommendations emphasize the importance of education, involving men in menstrual health discussions, and promoting proper hygiene practices.