Published Paper Details:

The first reference of Kupipakwa Rasayana is found in Rasaprakash Sudhakar of Acharya Yashodhara in 12th century where the formulation is named as Udayabhaskara Rasa in the context of Rasa bhasma. Kupipakwa Rasayanas are the unique Murchana yogas of Parada. The formulation are prepared in glass bottle with the aid of Valukayantra. Mercury has a great affinity to the sulfhydryls or thiols. The mercury atom or molecule will tend to bind with any molecule present that has sulfur or a sulfur-hydrogen combination in its structure. Hence, globules of Parada molecules disintegrated rapidly in sulfur during the preparation of Kajjali. There are also procedures and samskaras mentioned to potentiate the formulations or drugs. One such samskara (process) is mardana samskara that is used as a purification procedure of Parada as well as a bhavana for preparing Khalviya yogas (preparation made in mortar and pestle). SEM study suggests more fine nature of kajjali prepared in 7days(micron to nano size) than prepared in 2 days( 1 to 10 micron size) . 7)For the effective role in therapeutic bio-availability of metallic and mineral preparation,particle size is one of the important factor as it decides the permeability of drug through cells, tissues and blood capillaries.(Goldberg, M., Langer, R. and Xinqiao, J., Nanostructured materials for applications in drug delivery and tissue engineering. J. Biomater. Sci. Polym. Ed., 2007, 18(3), 241-268).