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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
Call For Paper - Volume 12 | Issue 7 | Month- July 2024
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Paper Title
DEVELOPMENT OF FORCED DEGRADATION STUDY
Authors
Aarti Sawant, Kiran Ghule, Yash Shegokar, Pranali Shewale, Prathamesh Solanke
Keywords
Lamivudine, Force degradation studies, UV-visible spectroscopy method
Abstract
A novel rapid, sensitive and reproducible mass compatible, ultra-performance liquid chromatographic method was developed for quantitative determination of Lamivudine in active pharmaceutical ingredients and its dosage forms. The synthetic nucleoside reverse transcriptase inhibitor analogues, Lamivudine form one of the fixed dosage combinations used in the effective management of HIV. It belongs to a group of anti-HIV medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs). The method is applicable to the quantification of related compounds of Lamivudine form one of the fixed dosage combinations. The developed HPLC method was further subjected to hydrolytic, oxidative, photolytic and thermal stress conditions. The performance of the method was validated according to the present ICH guidelines for specificity, limit of detection, limit of quantification, linearity, accuracy, precision, and ruggedness.
IJCRT's Publication Details
Unique Identification Number - IJCRT2403444
Paper ID - 253021
Page Number(s) - d704-d709
Pubished in - Volume 12 | Issue 3 | March 2024
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Aarti Sawant, Kiran Ghule, Yash Shegokar, Pranali Shewale, Prathamesh Solanke, "DEVELOPMENT OF FORCED DEGRADATION STUDY", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.12, Issue 3, pp.d704-d709, March 2024, Available at :http://www.ijcrt.org/papers/IJCRT2403444.pdf
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Volume 12 | Issue 7
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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