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ABSTRACT Background of the study: Cancer is a leading cause of death in the United States and worldwide. Cancer screening tests discover cancer at early stages, even before symptoms appear. When abnormal tissues or a malignant mass is found early, treatment and cure rates are improved. AIM: A present investigation was to assess the level of knowledge and perception towards prevention and early detection of cancer among Adult population in rural area. Materials and methods: 300 adult were selected making by random sampling technique. Data were analyzed by using descriptive and inferential statistical methods. Result: The study result shows that among adult, majority 146(48.7%) of adult population were in the age groups 41-50 years and very few 49(16.3%) were in the age groups of 31-40 years, majority 212(70.7%) of study participant were married and very few 88(29.3%) were singles, majority 140(46.7%) of the sample were studied secondary school and very few 77(25.7%) were studied primary school, majority 171(57.0%) of adult were civil servant and very few 30(10.0%) were doing others, majority 281(53.6%) of the participants were not working in health sector and very few 19(3.6%) were working in health sectors, majority 219(73.0%) had no chronic health problems and remaining 81(27.0%) had chronic health problems, majority 266(88.7%) of the adults had inadequate knowledge towards prevention and early detection of cancer, 34(11.3%) had moderately adequate knowledge and there were no adults with adequate knowledge. The study shows that there was no correlation between knowledge and perception towards prevention and early detection of cancer among adult and there was no association between knowledge score with selected demographic variables among study participants such as age, gender, marital status, education, occupation, area of work, working in health sector, family history, and chronic health problems. Conclusion: In this study, the research scholar concluded that there was no correlation between knowledge and perception towards prevention and early detection of cancer among adult.