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ABSTRACT Background of the study: During the past decades musculoskeletal disorders have been progressively common throughout the world. It is the one of the most common work related complication in working individual. Due to inactive and tiring lifestyle; there is a constant increase in severity, frequency and intensity of pain in neck that may cause stiffness and tension on areas of neck. Musculoskeletal complaints regarding neck region are extensively present in sewing machine workers. As this profession involves highly monotonous, repetitive work in sitting position with bent neck and upper part of back curved on the sewing machine for longer duration. This kind of effort requires greater concentration and precision.1 Aim of the study: To evaluate the effectiveness of isometric neck exercises among self employed sewing machine operators Methodology: The design selected for the study was pre experimental one group pretest - posttest design. 40 self employed sewing machine operators are selected by using non probability sampling technique (Convenient & purposive sampling). Knowledge was assessed through a pretested semi-structured questionnaire. ; Visual Analogue Scale for assessment of neck pain. Results: Present study revealed, majority 15(37.5%) of the self employed sewing machine operators were in the age groups 21-25 years and very few 4(10.0%) were in the age groups of 31-35 years, majority 22(55.0%) of the self employed sewing machine operators were males and 18(45.0%) were female, majority 28(70.0%) of the self employed sewing machine operators were married and remaining 12(30.0%) were singles, majority 26(65.0%) of the self employed sewing machine operators were belongs to the nuclear family and remaining 14(35.0%) were belongs to the joint family, majority 14(35.0%) of the self employed sewing machine operators had income between Rs11000-15000 and remaining 7(17.5%) had income between Rs5000-10,000, majority 14(35.0%) of the self employed sewing machine operators had work experience between 2-3 years and very few 6(15.0%) had work experience between 4-5 years, majority 29(72.5%) of the self employed sewing machine operators working 4-5 hours/day and very few 4(10.0%) working 2-3 hours/day, majority 30(75.0%) of the self employed sewing machine operators had not utilized rest hours and remaining 10(25.0%) had utilized rest hours, it was seen that out of 40 self employed sewing machine operators, majority 28(70.0%) had mild neck pain, followed by 7(17.5%) had moderate pain, very few 5(12.5%) had severe neck pain and there were no sewing machine operators with NO Pain. It was revealed that there was no association between neck pain of Self Employed Sewing Machine Operators with selected demographic variable such as utilization of rest hours, but pain score was highly associated with Age, gender, marital status, types of family, family income, work experience and working/day with chi-square p-value less than 0.0001. Conclusion: It was concluded that isometric neck exercise was highly effective in reducing pain among the self employed sewing machine operators.