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Introduction The incidence rate of Gridhrasi (sciatica) is quite significant as more than three-quarters of the world's population are affected by the disease. It is characterized by the onset of Ruja (pain), Toda (pricking), and Stambha (stiffness), initially in Sphik (gluteal region) and then radiating distally to Kati-Prishtha (low back), Janu (knee), Jangha (thigh) till Pada (feet). The patients suffering from Gridhrasi have restricted movements due to painful limb, affecting the daily routine activities. Aim To assess the role of Raktamokshana (blood letting) done by cups in the patients suffering from Gridhrasi. Materials and Methods The study was conducted on 15 patients who had reported for the treatment of Gridhrasi at an Ayurvedic hospital Raipur (C.G.). Raktamokshana was done on Sphik, Kati, Jangha, Pada region with the help of 24 no. surgical blade and cups in four settings (0, 7th, 14th and 21st day). The sign and symptoms, namely Ruka, Toda, Stambha, and Spandana (fasiculation) were given scores depending on their severity. The patients were also assessed for straight-leg raise (SLR) test. Follow-up was done at an interval of 15 days for three times and the scores were noted down before and after treatment. Results Marked reduction in severity of mean scores of Ruka, Stambha, Sakthiutkshepa Nigraha and walking time was seen in the patients after the use of Cupping therapy, which was statistically significant. Conclusions Cupping therapy is the simple and effective treatment (in adjunct to other treatment) for reducing Ruka, Toda, Stambha and Spandana in Gridhrasi.