Published Paper Details:

Pelletization is a process of agglomeration that converts fine powders or granules of bulk drugs and excipients into small, free flowing, spherical or semi-spherical units, known as pellets. Pellets are multiparticulate drug delivery system which suitable for promising and highly flexible system with various kinetics of drug release such as immediate release, sustained and controlled release which are easy to formulated. In order to eliminates the physicochemical interaction such as drug-excipient or drug-drug interactions multiparticulate dosage forms such as pellets can be implemented. Nowdays The process of pelletization as oral drug delivery system are gaining substantial attention. They form small spherical or semi-spherical free flowing solid units varying from 0.5 mm to 1.5 mm. Pellets are commonly used as multiparticulate systems as it has clinical as well as technical benefits as compared to single unit dosage forms. Pellet mainly for oral administration which can be further formulated into several other dosage forms such as tablets, capsules or can be administered as such. Oral administration has become the most versatile, convenient and common route of drug administration which ultimately focuses on patient compliance in present time. The present review focuses on process of pelletization, advantages, disadvantages, theory of pellet growth and formation, pelletization techniques, characterization of pellets, and also the recent approaches for pelletization techniques.