Published Paper Details:

Acyclovir used in Herpes Simplex Infection (e.g. cold sores, genital herpes), Herpes Zoster Infection (e.g. shingles) and Vericella Infection (e.g. chicken pox), is absorbed mainly from stomach and upper gastrointestinal tract. Food does not affect absorption of acyclovir. The dose of Acyclovir is 200 mg, 400 mg and 800 mg. The gastroretentive in-situ gelling drug delivery system can incorporate high dose (750-1000 mg) of the drug. The tablet for such a high dose will be large in size. Thus, it will not be patient compliant for patients having difficulty in swallowing, pediatrics, and geriatrics. Thus, the liquid dosage form is preferable. Dispersible tablets, conventional coated and uncoated tablets, capsules, suspensions, ointments and parenteral of Acyclovir are available in market. All these dosage forms show the half-life of 2-3 hours. Thus, dosing frequency is more. To reduce the dosing frequency, sustained release dosage form will be helpful.