Published Paper Details:

A major contributor to cardiovascular disease, atherosclerosis is an inflammatory vascular condition marked by a gradual buildup of cholesterol in the walls of the arteries. In recent years, problems with synthetic drug adverse effects have contributed to drug abuse. A new understanding of medicinal plants has therefore lately evolved, and extensive study has been done on these herbs in an effort to create novel organically based medications. The objective of this review paper was to examine the molecular processes of therapeutic plants with potential against atherosclerosis. The regulation of inflammatory factor expression, stimulation of PPARs, inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase), promotion of ATP-binding cassette transporter A1 (ABCA1) and ATP-binding cassette transporter G (ABCG), facilitation of adiponectin activity, reduction of LDL cholesterol, and stimulation of PPARs are just a few of the mechanisms by which an improved understanding of these herbal mechanistic linkages is a crucial step before designing new plant-based medications.. An important part of the aetiology of atherosclerosis is inflammation. Excessive intimal fibrosis, the development of fatty plaques, the growth of smooth muscle cells, and the migration of inflammatory-response cells including platelets, monocytes, and T cells are all symptoms of the condition. The early stage of atherosclerosis in cardiovascular illnesses is represented by low density lipoprotein (LDL) oxidation to Ox-LDL. Increased peroxynitrite concentrations in some clinical conditions, including severe hypercholesterolemia, worsen atherosclerosis and vascular damage. It has been proven that medicinal plants have the ability to interact with these or other pathogenic variables to inhibit atherosclerosis.