Published Paper Details:

The delivery of drugs through the mucous membrane of the mouth is thought to be a promising substitute for oral administration. Sublingual literally meaning is "under the tongue". Administrating substances is rapidly absorbed via blood vessels under tongue. The portionof drug absorbed through the sublingual blood vessels bypasses the hepatic first pass metabolism processes giving acceptable bioavailability. Sublingual tablet dissolve instantaneously, releasing the drug within a few second without the need of water and chewing. The objectives behind this review were to summaries the benefits of sublingual formulation, mechanismof action, advantages of route of administration, factor affecting permeability of drug, various in vitro evaluation parameters and commercially available sublingual dosage from. Sublingual tablet disintegrates rapidly and the small amount of saliva present is usually sufficient for achieving disintegration of the dosage form coupled with better dissolution and increased bioavailability. Different sublingual technologies address pharmaceutical industries and patient need to enhanced lifecycle and appropriate dosing for pediatric, geriatric, psychiatric patients also patients with dysphagia.