Published Paper Details:

Betel leaves, derived from the Piper betle plant, have been utilized for centuries across various cultures for their medicinal, cultural, and social significance. This paper presents a comprehensive review of the bioactive compounds found in betel leaves and their pharmacological properties. Betel leaves contain a plethora of phytochemicals including phenols, alkaloids, tannins, and essential oils, which contribute to their diverse biological activities. These bioactive constituents exhibit antioxidant, antimicrobial, anti-inflammatory, antidiabetic, anticancer, and gastroprotective properties, among others. Additionally, betel leaves possess analgesic, wound healing, and oral hygiene benefits. This review explores the mechanisms of action underlying these pharmacological effects, highlighting their potential therapeutic applications. Furthermore, considerations regarding toxicity, dosage, and formulation strategies are discussed. Overall, betel leaves represent a promising source of natural compounds with significant pharmacological potential, warranting further research to elucidate their mechanisms of action and optimize their therapeutic use.