Published Paper Details:

Stress is a pervasive phenomenon in modern society, and it has been strongly linked to a myriad of comorbid conditions. This comprehensive review aims to explore the intricate relationship between stress and its comorbidities, taking into account various aspects such as psychological, physiological, and behavioral factors. The review delves into the multifaceted impact of stress on mental health, including its role in the development and exacerbation of anxiety disorders, depression, and post-traumatic stress disorder. Furthermore, it uncovers the intricate interplay between stress and physical health, shedding light on how chronic stress can contributed to cardiovascular disease, immune system dysregulation, and metabolic disorders. In addition, the review examines the behavioral repercussions of stress, exploring its influence on substance abuse, addictive behaviors, and disrupted sleep patterns. Special attention is a given to the neurobiological pathways through which stress exerts its effects, including the hypothalamic- pituitary-adrenal axis and the sympathetic nervous system. Furthermore, the review discusses the important early intervention and effective stress management strategies in mitigating the risk of comorbid conditions. It highlights the role of cognitive- behavioral therapy, mindfulness-based interventions, pharmacological approaches in addressing stress and its associated comorbidities. By synthesizing evidence from diverse fields, this review presents a comprehensive understanding of the complex relationship between stress and comorbid conditions. It underscores the imperative for tailored interventions that consider the intertwined nature of stress and its comorbidities, aiming to pave the way for more effective therapeutic approaches and improved health outcomes.