Published Paper Details:

Oral administration is the most convenient and preferred means of any drug delivery to the systemic circulation.Controlled-release drug delivery systems (CRDDS) provide drug release at a predetermined, predictable and controlled rate required for therapeutic effect. To improve the solubility and bioavailability of poorly water soluble drugs, solid dispersions is the most frequently used. Amongst solid dispersions, lipid based carriers had a higher success rate in enhancing the bioavailability of Class II drugs (Furosemide), one such promising group of carrier is Phospholipid (soyalecithin). The aim of the present work was to prepare phospholipid solid dispersion of Furosemide (PLD) with soy lecithin in different ratios using solvent evaporation method. The prepared PLD4 was used to prepare core tablets (F1-F5) using polymers HPMC K4M & E15, which were further subjected to compressed coat (C1-C5) using sodium bicarbonate, PVP K 30 and HPMC E5. Post-compression parameters of Furosemide tablets were evaluated. Formulation F4 core tablet was optimized having drug release of 93.31% in 12 hrs, drug content was 99.50%, floating lag time 16sec with floating time 12 hrs. Among compressed coated floating tablets of Furosemide, C3 has shown 93.31% release with zero order release pattern.