Published Paper Details:

Ethosomes are non-invasive delivery devices that allow drugs to reach the deeper layers of the skin and the systemic circulation. Although ethosomal systems are conceptually advanced, their preparation is a simple and safe combination that can greatly expand their application. Ethosomes are soft, malleable vesicles adapted to improve the transport of active substances. Due to their unique structure, Ethosomes are able to encapsulate and carry through the skin very lipophilic molecules such as cannabinoids, testosterone and minoxidil, as well as cationic drugs such as propranolol, trihexaphenidyl, cyclosporine, insulin, salbutamol. Enhanced transport of bioactive molecules through the skin and cell membranes by an ethosomal carrier opens up many challenges and opportunities for research and further development of new, improved therapies. Ethosomes are gaining popularity in the design of drug delivery systems for topical and transdermal use because they can reach deep skin layers and systemic circulation. Although conceptually advanced, Ethosomes are easy to make and safe to use. Although very efficient, Ethosomes offer the potential for expanding applications. The purpose of the review is to give an in-depth overview of the properties and preparation of Ethosomes, followed by a characterization and list of drugs encapsulated in Ethosomes over the last 15 years