Published Paper Details:

Nucleic acid vaccines, in particular messenger RNA (mRNA) vaccines, show notable benefits in the current COVID-19 pandemic. The nucleic acid vaccine's potential as a preventative and therapeutic measure has been greatly increased by the use of polymeric materials as delivery vehicles. Improved in vivo stability, enhanced biosafety, selective cellular absorption, endolysosomal escape, and promoted antigen expression are among the features of polymeric nucleic acid vaccines. Nevertheless, polymeric the hurdles facing polymer-gene vaccination systems are still too great, despite significant advancements in the past few decades in the delivery of nucleic acid vaccines and clinical translation. An overview of different polymers and their properties, as well as sample formulations, are given in this review for the delivery of vaccines containing nucleic acids. It also explores the issues that are currently being faced in this field, how to solve them, and the potential uses of polymeric carriers and nucleic acid vaccines. This review's main objective is to protect against serious or emerging diseases by rationally designing and developing polymeric vaccine delivery systems. This review also includes information about recently developed novel delivery platforms and new vaccine vectors.