Published Paper Details:

The primary objective of drug delivery systems is to attain a therapeutically effective and non-toxic concentration of the drug in the bloodstream or tissues over an extended period. Numerous endeavors have been undertaken to develop gastroretentive delivery systems, encompassing high-density formulations, swelling systems, and floating systems. This comprehensive review delves into recent advancements in Floating Drug Delivery Systems (FDDS), elucidating the physiological and formulation variables influencing gastric retention. It expounds upon methodologies for designing both single-unit and multiple-unit floating systems, providing a detailed classification and examination of formulation aspects. Furthermore, the review synthesizes findings from studies evaluating the performance and applications of floating systems, shedding light on their various uses. Given the intricacies of gastric emptying, a process introducing uncertainty to the in vivo performance of drug delivery systems, concerted efforts have been directed towards extending the retention time of these systems beyond 12 hours. In this context, hydrodynamically controlled drug delivery systems, particularly those employing floating mechanisms, prove advantageous