Published Paper Details:

Background: Oral Squamous Cell Carcinoma (OSCC) poses a significant global health challenge, necessitating a nuanced understanding of its molecular underpinnings for improved diagnostics and therapeutic interventions. MicroRNA-21 (miR-21) has emerged as a key player in OSCC, demonstrating intricate involvement in tumorigenesis and offering potential clinical applications. Methods: A comprehensive exploration of miR-21 in OSCC was conducted, encompassing its oncogenic nature, progressive expression patterns, diagnostic potential, therapeutic implications, and clinical significance. The analysis included studies on miR-21's functional diversity, its diagnostic utility in lesion progression, and the use of targeted interventions to inhibit tumor formation. Results: MiR-21 exhibits a multifaceted role in OSCC, extending beyond cell proliferation to intricate regulatory functions in inflammatory pathways. Its progressive expression patterns throughout lesion development position it as a promising diagnostic marker, detectable in non-invasive samples. Antisense oligonucleotide-based interventions demonstrate therapeutic potential, suggesting miR-21 as a viable target for precision medicine. Conclusion: The study underscores miR-21's central role in OSCC, presenting a dynamic landscape of diagnostic and therapeutic opportunities. As a potential biomarker, prognostic indicator, and therapeutic target, miR-21 holds promise for personalized approaches in oral cancer management. Further research, including exploration of molecular intricacies and crosstalk, is warranted for transformative breakthroughs in OSCC diagnosis and treatment.