Published Paper Details:

ABSTRACT Background: A Common sleep disorder such as insomnia is characterized by persistent problems falling asleep, staying asleep, or experiencing nonrestorative sleep that impairs functioning during the day. Regardless of the proper conditions for sleeping every night, the sleep disruptions associated with insomnia typically manifest as difficulties falling asleep, trouble staying asleep, or waking up too early. A person's quality of life can be negatively impacted by insomnia, which can lead to frequent daytime naps, difficulty focusing, an increased risk of mistakes and accidents, and lower productivity at work. A multidisciplinary strategy is recommended for the treatment of insomnia, with an emphasis on pharmacological therapy, behavioral treatments, better sleep hygiene, psychological stress management, and hypnotic treatment. In order to limit the required dosage and any associated side effects, the most successful treatments combine medication with cognitive behavioral therapy. The most often utilized hypnotics as supplementary therapy are non-benzodiazepine ones like zaleplon, eszopiclone, and zolpidem. Zolpidem is one of these hypnotics that is most often utilized. But zolpidem has a lot of adverse effects, and the literature has a few distinctive features to keep in mind. Objective: To carry out a comprehensive analysis of adverse events associated with zolpidem. Method: A variety of websites, including PubMed, Google Scholar, Science Direct, Seizure Journal, Elsevier, Medscape, WHO Pharma Newsletter, Research Gate, Springer Link, and Online Library Wiley, were reviewed in the preparation of this review study. Observation: Owing to its superior safety profile over benzodiazepines, zolpidem is one of the most often given medications for insomnia. But zolpidem usage is associated with a number of neuropsychiatric side effects that should be taken very seriously, including hallucinations, sensory distortions, delirium, parasomnias or complex sleep behaviors (CSBs), amnesia, somnambulism, sleep-related eating disorders, suicidality, etc. When prescribing a medication, medical practitioners should be cautious and mindful of its potential harmful effects. Study Eligibility Criteria: Scholarly articles of any kind (case reports, case series, observational or interventional studies) that detail zolpidem's neuropsychiatric side effects.