Published Paper Details:

This review investigates the relationship between Human Serum Paraoxonase 1 (PON1) activity and complications in Type 2 Diabetes Mellitus (T2DM). Recognizing the critical role of PON1 as an antioxidant enzyme associated with HDL. A comprehensive literature review spanning from 2013 to 2023 was conducted, utilizing PubMed, Scopus, and Web of Science databases. The search strategy incorporated relevant keywords and medical subject headings (MeSH) related to "Paraoxonase 1," "Type 2 Diabetes Mellitus," and associated complications. To enhance search precision, Boolean operators were used. Compromised PON-1 activity was consistently identified in T2DM, showing correlations with dysregulated lipid markers, cardiovascular complications, atherosclerosis, diabetic nephropathy, and diabetic retinopathy. Gender-specific variations in PON-1 activity, particularly pronounced in women, were also observed. There is a bidirectional relationship between diabetes and PON-1 and it can be used both as a diagnostic and prognostic marker, assessing risk and complications in T2DM. Further research is necessary to validate these findings and pave the way for targeted therapeutic interventions encompassing diverse populations.