Published Paper Details:

Solubility is the process by which a solid dissolve in a liquid phase to form a homogeneous mixture. The aqueous solubility of drug affect the physical, chemical & dose stability; it sets a standard for purity, dissolution rate and extent of absorption. A majority of active pharmaceutical ingredients that are being developed (drug) are lipophilic with limited aqueous solubility leading to problems in preclinical pharmacokinetic and toxicological investigations. Due to rapid advancement in combinatorial chemistry, high-throughput screening this increase of poorly aqueous soluble drugs have been observed. Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. Solid dispersions of poorly water-soluble drugs with water-soluble carriers have been reduced the incidence of these problems and enhanced dissolution. The focus of this review article on advantages, disadvantages and the method of preparation, and characterization of the solid dispersion.