Published Paper Details:

Abstract: Around the world, the number of cases of diabetes has been rising rapidly in recent decades, and one of the most exciting fields of research is the search for small chemicals with strong anti-diabetic properties. Diabetes mellitus (DM) is a chronic metabolic condition characterized by an increase in blood glucose levels due to an imbalance in glucose homeostasis [1, 2]. Two relatively prevalent risk factors that contribute to both neurological diseases and cardiovascular disease are type 2 diabetes and hypertension [3]. With decades of history and potential for growth, heterocyclic chemistry has dominated the field and is essential to the synthesis of new medications. Among the heterocycles, triazoles and coumarins received the most attention due to their significant biological activity and natural occurrence. Coumarins are prepared via Pechmann condensation, catalytic annulation phenolic acetates with acrylates [4], ZnBr2 catalyzed reaction of salicylaldehyde with ynamides [5], Amberlyst-15 catalyzed reaction of 1,3-dihydroXybenzene and ethyl acetoacetate under micro- wave irradiation in a solvent free conditions [6] etc. Naturally occurring coumarins in the glycoside forms are useful in medicine [7], and coumarins shows antimicrobial [8], anti-HIV [9], radical scavenging [10], and anti-viral [11] properties.