Published Paper Details:

This research introduces a groundbreaking approach in dermatological treatment, focusing on the development of a Microsponges-loaded topical hydrogel for the effective management of plaque psoriasis. The study underscores the advantages of transdermal drug delivery, emphasizing the convenience, increased patient compliance, and localized therapeutic effects offered by topical applications. Microsponges, characterized by their porous microspheres, play a pivotal role in controlling drug release, enhancing stability, and reducing side effects. The versatility of Microsponges in encapsulating various active ingredients, such as anti-inflammatory agents and essential oils, makes them a promising candidate for dermatological applications. The article explores the pathophysiology of psoriasis, detailing its autoimmune and T cell-mediated nature, affecting approximately 125 million people worldwide. Plaque psoriasis, the most common type, is characterized by dry, itchy, raised patches on the skin. The proposed Microsponges-loaded hydrogel aims to address the limitations of current treatments by extending the contact time of active ingredients on the skin, minimizing systemic absorption, and optimizing therapeutic outcomes. Furthermore, the research incorporates hydrogel technology, known for its three-dimensional structure and water-holding capacity. This integration enhances the overall formulation by providing controlled drug release, improved stability, and ease of application. The article discusses the advantages and disadvantages of hydrogels, emphasizing their biocompatibility, flexibility, and potential for modification. In vitro release studies using a Franz diffusion cell and stability evaluations following ICH specifications provide insights into the performance and longevity of the proposed formulation. The study concludes that the microsponge-loaded topical hydrogel offers a promising avenue for psoriasis treatment, potentially revolutionizing current therapeutic strategies. This innovative approach not only addresses the challenges associated with conventional treatments but also provides a foundation for further research in transdermal drug delivery and dermatological applications.