Published Paper Details:

Bilayer tablet represents new era for the successful development of controlled release formulation along with various features to produce of the successful drug delivery system. According to the literature review of the past decade, bilayer tablets have been developed to achieve sequential release of two drugs in which one layer is immediate release layer and the second layer as sustained release layer. Bilayer tablets can be a primary option to avoid chemical incompatibilities between api by physical separation, and to enable the development of different drug release profiles like the immediate release with extended release. Bilayer tablet is suitable for sequential release of two drugs in combination or to incorporate two incompatible substances in same tablet. Bilayer tablet have improved beneficial technology to overcome the problems of the single layered tablets. Productions of quality bilayer tablets needs to be carried out and to reduce the common bilayer problems, such as layer-separation, insufficient hardness, Inaccurate individual layer weight control, cross- contamination between the layers, Therefore, now a day's bilayer tablet have been developed for combination therapy for treatment of various diseases such as anti-inflammatory, anti- hypertension, anti-diabetic and analgesic. And also disorder requiring long term therapy such as hypertension diabetes mellitus, rheumatoid arthritics. . The primary objective of bilayer tablet is sustained release drug delivery is to improve the oral therapeutic efficacy with optimal control of plasma drug level and also improve its bioavailability which in turn improve the patient compliance and convenience. . The present article explains introduction to bilayer tablets, Advantages, technology challenges in bilayer tablet manufacturing, various tablet presses used, quality and GMP requirements for their manufacturing various techniques used for bilayer tableting and recent advancement in the field of bilayer technology.