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Background: Psychoactive substance use disorder is one of the most common psychiatric disorders that has deleterious consequences not only the patient with psychoactive substance users but also hampers social, financial ,and legal matters of his family hence could be considered as a disorder of the family spouses of patients with psychoactive substance use disorder , a key member of dysfunctional family system, are most vulnerable to have significant psychiatric disorders like adjustment disorders, mood disorders, anxiety disorders and psycho-social problems. Hence, we have undertaken this study in order to understand and address such issues which is largely neglected in psychiatric research. Materials and Method: Quantitative research approach, research design in this study is Experimental study design, non-probability convenient sampling technique used. A study conducted on caregivers of psychoactive substance users. The sample size was 95. By using the self-structured questionnaire knowledge regarding psychoactive substances and home care management was assess ed. Time given to fill the questionnaire was 30 minutes. Result: Percentage wise distribution of pre-test and post-test knowledge of caretaker depicts that highest percentage in pretest (64.22) had average knowledge, (32.63%) of them had poor knowledge and in post-test (70.53%) of the respondents had good knowledge. Hence it can be interpreted that self-instructional module was effective in improving the knowledge regarding psychoactive substances and homecare management of caretaker. Hypothesis testing was done by using 't' test and chi-square test. t value was calculated to analyze the difference in pre-test and post-test knowledge score of caretakers. Highly significant difference was found between pre and post-test knowledge score of caretakers (17.100). Hence the stated null hypothesis is rejected as it is interpreted that there was significant difference between pre-test and post-test knowledge score regarding psychoactive substances and homecare management. Chi-square test is applied for association between pre-test study findings and selected demographic variables. Chi-square values for this test are respectively for Age is (?2=4.591), Gender is (?2=10.671), educational qualification is (?2=3.972), Occupation is (?2=1.585), Family income is (?2=13.971), Type of family is (?2=2.587), relation with patient is (?2=16.080) and for drug does your patient consume is (?2=5.621) Conclusion: The focus of this study was to assess effectiveness of self-instructional module on knowledge regarding psychoactive substances and homecare management among caretakers of psychoactive substances users in tertiary care hospital of the city. In this study One group pretest post-test design with quantitative research approach was used. 95 samples were selected from selected hospitals of the city by using non-probability convenient sampling technique. The data was collected by using Self- structured Questionnaire on knowledge of caretakers of psychoactive substances and home care management. Self-Instructional module on psychoactive substances and home care managements. Data was analyzed and interpreted by applying statistical method. The researcher felt deep sense of satisfaction and fulfilment at having undertaken the study. The study provided deeper insight and empathy towards the needs of the expert guidance from the guide and cooperation of teachers has made the study a fruitful and pleasant experience.