Published Paper Details:

Abstract: Asthma is chronic inflammatory disorder of the airway. This feature of asthma has implication for the diagnosis, management, potential and prevention of the disease. Airway inflammation contributes to airway hyper responsiveness, airflow limitation, respiratory symptoms, and disease chronicity. In some patient, persistent changes in airway structure occurs, including sub- basement fibrosis, mucus hyper secretion, injury to epithelial cell, smooth muscle hypertrophy and angiogenesis. Gene by environment interaction are important to the expression of asthma. Viral respiratory infections are of the most important causes of asthma and also contribution to development of asthma. The onset of asthma for most patient beings early in life with the pattern diseases persistence determined by early. Recognized risk factors including atrophic diseases recurrent wheezing and patient history of asthma. Current asthma treatment with anti-inflammatory therapy does not appear to prevent progression of the underlying diseases severity. The critical role inflammatory has been further substantiated but evidence in emerging for considerable variability in the pattern of inflammation. The immunohistopathologic feature of asthma include inflammatory cell in filtration. o Eosinophills o Lymphocytes o Mast cell activation