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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
Development And Validation of UV Spectrophotometric Method For Estimation of Glipizide In Bulk Drug and Pharmaceutical Formulation
Authors
Ms.Madhuri Balasaheb kanawade, Mr.Siddhant Jondhale, Mr.Vishal Kale
Keywords
KEYWORDS: Method Validation , Glipizide
Abstract
A selective, simple, accurate and reproducible spectrophotometric method has been developed for the estimation of Glipizide in bulk and pharmaceutical formulation. Glipizide is a second generation sulfonylurea which lowers blood glucose in patients with diabetes mellitus type II. The drug obeyed the Beer's law and showed good correlation. It showed absorption maxima at 275 nm in 0.5N NaOH. The developed method was validated with respect to linearity, accuracy and precision in accordance with the requirements of ICH guidelines. The linearity was observed between 10-30?g/ml having line equation Y= 0.0219X + 0.0 132 with correlation coefficient of 0.999.The limit of quantification and limit of detection were found to be 1.892 and 0.624 ug/ml respectively. Moreover, the proposed analytical method is thus potentially useful for a routine laboratory because of its simplicity, rapidity, precision and accuracy.
IJCRT's Publication Details
Unique Identification Number - IJCRT2312903
Paper ID - 247641
Page Number(s) - i10-i13
Pubished in - Volume 11 | Issue 12 | December 2023
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Ms.Madhuri Balasaheb kanawade, Mr.Siddhant Jondhale, Mr.Vishal Kale, "Development And Validation of UV Spectrophotometric Method For Estimation of Glipizide In Bulk Drug and Pharmaceutical Formulation", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 12, pp.i10-i13, December 2023, Available at :http://www.ijcrt.org/papers/IJCRT2312903.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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