Published Paper Details:

Simple, precise, economical, fast and reliable two UV methods have been developed for the simultaneous estimation of Metformin HCl and Glimepiride in bulk and pharmaceutical dosage form. Method A is Absorbance maxima method, which is based on measurement of absorption atmaximumwavelength of236 nm forMetforminHClrespectively. Method Bisareaunder curve (AUC), in the wavelength range of 217-247 nm for Metformin HCl. Linearity for detector response was observed in the concentration range of 5- 25?g/ml for Metformin HCl .The accuracy of the methods was assessed by recovery studiesandwas foundto be 100.23 % for Metformin HCl respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The results were validated statistically as per ICH Q2 R1 guideline and were found to be satisfactory. The proposed methods were successfully applied for the determination of for Metformin HCl in commercial pharmaceutical dosage form.