Published Paper Details:

Now a days food adulterant is commonly used in food industry because of excessive production and preservation of food. Melamine is a food adulterant which has several industrial uses. There are various toxicological reports about the health effect of melamine on various organ of experimental and human system. There is a knowledge gap about the toxic effect of melamine on digestive system or duodenal contraction. The objective of our present study was to examine the probable toxic effect of melamine on contraction of duodenum. We used here male albino rat for our experiment for 5% and 10% of LD50 doses of melamine and 28 days treatment duration. We observed from our study that both frequency of contraction and force of contraction duodenum were increased in both the experimental doses compared to the duodenal contraction of control rat. We also observed significant degenerative changes in the cell layers of duodenum. From this results we may concluded that melamine facilitate the duodenal contraction by augmenting the cholinergic neuronal pathway.