Published Paper Details:

The historical significance of medicinal plants in healthcare has long been acknowledged for their myriad health benefits. This study aimed to develop a novel herbal syrup formulation using Allium cepa, which underwent comprehensive evaluation for various properties such as pH, homogeneity, appearance, spradability, viscosity, and in-vitro diffusion. The formulation labelled as F3 exhibited favourable attributes across all criteria, suggesting the successful preparation of an effective Allium cepa herbal syrup using a specific polymer, enhancing its application properties. Additionally, a review highlighted the extensive spectrum of effects exhibited by Allium cepa, commonly known as onion, and its constituents on diverse disorders in both experimental and clinical studies. Experimental research showcased the plant's anti-cancer potential, including chemo-preventive and inhibitory effects on skin tumorigenesis, metastatic growth inhibition, and modulation of cancer cell proliferation. Clinical trials supported these findings, indicating reduced risks of brain and lung cancers owing to the flavonoids present in onions. Moreover, experimental evidence revealed the plant's role in managing blood glucose levels, enhancing serum insulin levels, and protecting pancreatic islets. Clinical trials further supported the Reduction effects of onions on blood glucose levels The review also documented the plant's inhibitory effects on platelet aggregation, cardiovascular benefits such as blood pressure reduction, vasodilation, and protection against myocardial infarction. On gastrointestinal health, onions demonstrated anti-spasmodic, anti-diarrheal, and anti-ulcer effects, along with improvements in memory deficits and behavioural issues. In respiratory health, Allium cepa displayed anti-asthmatic properties, reducing inflammation and improving lung function. Furthermore, the plant exhibited positive effects on the urogenital system, enhancing reproductive health and showing diuretic effects, among other benefits. The comprehensive pharmacological effects observed in experimental studies underscored the potential therapeutic applications of onions. However, the review emphasized the necessity for more extensive clinical trials to validate these effects before considering their application in clinical practice.