Published Paper Details:

Generating and evaluating Metformin HCL gastroretentive tablets is the fundamental objective of this present study. Metformin HCL belongs to the biguanide class which is an oral anti- diabetic drug. It is used to treat for type-2 diabetes Metformin HCL is recognised as corresponding to class 3 in the Biopharmaceutical classification system (BSC). It is important to ensure that Metformin HCL tablets must possess low permeability and high solubility. Metformin HCL pills are produced utilising four distinct types of synthetic polymers.They are Hypromellose K6 LV, Hypromellose E15LV, Hypromellose K100MPCR, Hypromellose K100LV. These synthetic polymers will impact the buoyancy mechanism on the tablet. Metformin HCL gastroretentive tablets are prepared by using two techniques.one is wet granulation method, and another one is top spray granulation method. In this study Four formulations were prepared. After formulation of tablets should be subject to different types of evaluation tests like weight variation test, thickness,hardness,friability test, Floating Lag time, total floating time, invitro dissolution studies and kinetic drug release studies. All the results are within the limits. Formulation 2 shows the highest drug release in dissolution studies.Studies on the kinetic discharging of chemical substances have been carried out employing formulation 2, which at first was regarded as to be the optimum formulation. All the results are within the limitation and satisfactory.