Published Paper Details:

Skin as a drug delivery method has attracted great attention in recent years because it eliminates many of the limitations of oral and parenteral administration. However, the excellent barrier properties of skin are a major obstacle to effective drug delivery via this route. The top layer of the skin, the "stratum corneum", is the tightest layer and is responsible for most resistance. This requires a reversal and change in the resistance of the stratum corneum to achieve significant cure in systemic or localized skin diseases. In the last few years, many methods have been developed to increase the permeability of drugs through the stratum corneum. A good way is to use nanoparticle materials, as they not only facilitate the delivery of drugs into the skin, but also prevent negative effects on the skin structure. This review focuses on nanoparticle carriers, including liposomes, deformable liposomes, ethosomes, liposomes, and lipid nanoparticles designed for topical and transdermal delivery. Special attention is paid to their composition, structure, access process and final applications. The data presented demonstrate the potential of the nanoparticle carrier for dermal and transdermal delivery.