Published Paper Details:

Oral therapy of (NSAIDS) is for the treatment of rheumatoid arthritis causes gastric irritation and ulceration. Ketoprofen has a half life of 1.5 hrs and the bioavailability of ketoprofen is 86% . The total daily dose of ketoprofen is 75 mg , hence it requires frequent dosing. Emulgel was prepared for dual controlled release of drug from emulsion and gel also avoids first pass metabolism. Different formulations were prepared using different hydrotropes sodium acetate , sodium citrate and urea in both the solid and liquid state by solid dispersion method. The prepared formulation were evaluated for various parameters like viscosity, pH, skin irritation, extrudability and invitro permeation using Franz diffusion cell . Diffusion data was fitted into various kinetic models (zero order , first order , Higuchi ,Korsemeyer peppas model). The formulation containing the combination of hydrotropes in the ratio 1:3 in 10% using almond oil as permeation enhancer was considered optimum batch and showed similar drug release to the marketed ketoprofen formulation.