Published Paper Details:

Triclosan (TCS) is commonly used as an antibacterial and antifungal agent in household cleaning products. TCS can be bio-accumulated and create endocrine-disrupting and damaging the DNA in some exposed fish. In the present study aimed at verifying the productive effect of garlic extract (GRE) and Vitamin C (VTC) against in vivo tricolosan exposure in zebra fish Brachydanio rerio (Ham). The species were exposed to sub lethal concentration of triclosan (0.32mg/L) for 7 and 28 days. The results show that TCS exposure significantly induced genotoxic effects, as revealed by the significant increase in the mean frequencies (MN) of micro nucleated polychromatic erythrocytes and various structural chromosomal aberrations in liver cells of treated fish. GRE and VTC groups showed a significant (P< 0.05) reduction in the frequency of CA (57.14% and 40.66%) and MN (53.13% and 40.63%) then the treated group. On the other hand, this investigation clearly revealed the protective effect of GRE and VTC, either each alone or in combination, against the genotoxic potential of triclosan: the garlic extract was often more efficient in its protective action against the pesticide toxicity than vitamin C.